At Moffitt Cancer Center, we strive to be the leader in understanding the complexity of cancer and applying these insights to contribute to the prevention and cure of cancer. Our diverse team of over 9,000 are dedicated to serving our patients and creating a workspace where every individual is recognized and appreciated. For this reason, Moffitt has been recognized on the 2023 Forbes list of America’s Best Large Employers and America’s Best Employers for Women, Computerworld magazine’s list of 100 Best Places to Work in Information Technology, DiversityInc Top Hospitals & Health Systems and continually named one of the Tampa Bay Time’s Top Workplace. Additionally, Moffitt is proud to have earned the prestigious Magnet® designation in recognition of its nursing excellence. Moffitt is a National Cancer Institute-designated Comprehensive Cancer Center based in Florida, and the leading cancer hospital in both Florida and the Southeast. We are a top 10 nationally ranked cancer center by Newsweek and have been nationally ranked by U.S. News & World Report since 1999. Working at Moffitt is both a career and a mission: to contribute to the prevention and cure of cancer. Join our committed team and help shape the future we envision. Summary Postdoctoral Fellow in Cancer Biology A postdoctoral position is available in Dr. Lixin Wan’s group at Moffitt Cancer Center Department of Molecular Oncology. The research in Dr. Wan’s lab is focused on protein post-translational modifications. We are interested in understanding how these modifications are misregulated in tumor cells, tumor-infiltrating immune cells, and tumor-interacting stroma cells. We are also interested in developing next-generation techniques to characterize these modifications. Our current projects include the multifaceted roles of ITCH in melanoma and the melanoma immune microenvironment, the context-dependent functions of master cell cycle regulator APC/C in breast cancer and ovarian cancer, the crosstalk between tumor cell aneuploidy and innate immunity, and several others. The lab uses a wide range of approaches in our projects: molecular biology, protein biochemistry, in vitro cell culture models, xenograft and syngeneic mouse models, genetically engineered mouse models, various CRISPR-based techniques, and genomic/transcriptomic/proteomic omics techniques. Our recent representative publications: Qing et al, Nature Communications 2019; Han et al. Nature Communications 2019; Dai et al. Cell Reports 2022. Others can be found on Dr. Wan’s Google Scholar page: The Ideal Candidate: • Experienced in molecular biology, cell biology and biochemistry techniques including cloning, virus delivery system, CRISPR/Cas9 system, DNA/RNA manipulation, protein purification, and immunoblot. • Animal handling, mouse modeling and small animal imaging experience. • Basic imaging techniques including immunofluorescence, live color imaging. • Basic bioinformatics skills. • Previous experience in next-generation sequencing techniques (RNA-seq, ChIP-seq, etc) and/or proteomics is a plus. • Previous immunology experience is a plus. Responsibilities : • Work with PI on the project planning; design and conduct experiments independently; document and organize the data routinely. • Learn and develop research techniques and lab protocols. • Develop scientific writing and presentation skills. • Work with collaborators and core facility staff on interdisciplinary experiments. • Supervise research assistants and graduate students. Credentials and Qualifications: • MD or PhD in Cancer Biology, Molecular and Cellular Biology, Genetics or related.aa415a4b-8b21-40fc-a65c-70d2b25ca29a
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